Absolutely, A Thousand Times No Right Turn

No Right Turn - The New York Times:

...But at least some commentators are calling on her to do something very different — to make a right turn, moving the Democratic agenda toward the preferences of those fleeing the sinking Republican ship. The idea, I guess, is to offer to create an American version of a European-style grand coalition of the center-left and the center-right.

I don’t think there’s much prospect that Mrs. Clinton will actually do that. But if by any chance she and those around her are tempted to take this recommendation seriously: Don’t...

If personal experience were not enough, Clinton ought to look at Obama's first term to understand what trying to work with Republicans will get you: less than nothing.